Anti-Alzheimer, antioxidants, glucose-6-phosphate dehydrogenase effects of <i>Taverniera glabra</i> mediated ZnO and Fe₂O₃ nanoparticles in alloxan-induced diabetic rats

Abstract The current study aimed to assess the neuroprotective effect of Zn and Fe oxide nanoparticles biofabricated by Taverniera glabra in alloxan-induced diabetic rats. experimental animals (160–200 g) were divided into nine groups ( n = 9). blood glucose, body weight, glucose-6-phosphate dehydrogenase (G6PD), superoxide dismutase (SOD), catalase test (CAT), lipid peroxidation (TBARS), glutathione (GSH), acetylcholinesterase (AChE) activities determined. Oral administration T. methanol extract (TGME; 10 15 mg/kg b.w) significantly decreased glucose level, increased controlled quantitative level G6PD, levels ALT, ALP, cholesterol, creatinine. Moreover, TGME their restored antioxidant enzymes (SOD, CAT, GPx, GSH) that during induced diabetes. In group, a significant increase TBARS was noted recovered p &lt; 0.05) as compared glibenclamide. AChE activity both brain group 0.05). Taken together, it can be suggested improved memory could considered an effective biogenic nanomaterial for diabetes, Alzheimer’s disease, oxidative stress.